The ANCC FNP-BC blueprint emphasizes five domains: Assessment and Diagnosis (history-taking, physical exam, ordering diagnostics, differential diagnosis); Health Promotion (screening, immunizations, preventive counseling, health literacy); Management of Patient Health (pharmacology, chronic disease management, acute care across the lifespan — pediatrics through geriatrics); Professional Role (ethics, scope of practice, care coordination, billing basics); and Research/Theory (evidence-based practice, quality improvement). High-yield clinical areas include cardiovascular, pulmonary, dermatology, women's health, mental health, and musculoskeletal.